A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) A61K 31/395 (2006.01) A61K 38/18 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C07K 14/52 (2006.01) C07K 14/535 (2006.01) C07K 14/715 (2006.01)
Patent
CA 2659337
Methods to mobilize progenitor and/or stem cells from the bone marrow to the bloodstream by administering a combination of at least one CXCR4 inhibitor, at least one CXCR2 agonist, and G-CSF are described. The combinations may also be used to increase the effectiveness of chemotherapy and radiation therapies for hematopoietic malignancies.
La présente invention concerne des procédés permettant de mobiliser des cellules progénitrices et/ou des cellules souches de moelle osseuse dans la circulation sanguine grâce à l'administration d'une combinaison d'au moins un inhibiteur CXCR4, d'au moins un agoniste CXCR2, et de G-CSF. Les combinaisons peuvent également être utilisées afin d'accroître l'efficacité d'une chimiothérapie et de thérapies de rayonnement destinées à traiter des malignités hématopoïétiques.
Bridger Gary
Pelus Louis M.
Fetherstonhaugh & Co.
Genzyme Corporation
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