Combination therapy

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/53 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2608473

This invention relates to a therapeutic combination of anti-cancer compounds which comprises a) a VEGFR-2 inhibitor, and b) a substance that binds to the epidermal growth factor receptor (EGFR) and blocks the ability of epidermal growth factor (EGF) to initiate receptor activities which results in tumor growth inhibition, and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use.

L'invention se rapporte à une combinaison thérapeutique constituée de composés anticancéreux qui comprend (a) un inhibiteur du VEGFR-2 et (b) une substance qui lie le récepteur du facteur de croissance épidermique (R-EGF) et bloque la capacité du facteur de croissance épidermique (EGF) afin d'initier les activités du récepteur, ce qui a pour effet d'empêcher la croissance de la tumeur, et éventuellement d'au moins un vecteur pharmaceutiquement acceptable utilisé simultanément, séparément ou séquentiellement.

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