Combination therapy associating a tgf-beta antagonist with a...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/11 (2006.01) A61K 31/04 (2006.01) A61K 31/166 (2006.01) A61K 31/52 (2006.01) A61K 31/7048 (2006.01) A61K 31/7125 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2550058

The invention concerns a pharmaceutical composition comprising at least one stimulator of the immune cell functions and at least one substance inhibiting the cell proliferation and/or inducing cell death. In a preferred embodiment the stimulator of the function of the immune system and/ or the immune cells are antagonists of TGF-beta selected from the group of oligonucleotides hybridizing with an area of the messenger RNA and or DNA encoding TGF-beta and the at least one substance inhibiting cell proliferation and/or inducing cell death is selected from the group of temozolomide, nitrosoureas, Vinca alkaloids, antagonists of the purine and pyrimidines bases, cytoststatic active antibiotics, caphthotecine derivatives, anti estrogens, anti-androgens and and analogs of gonadotropin releasing hormon.

L'invention concerne une composition pharmaceutique comportant au moins un stimulateur des fonctions de cellules immunitaires et au moins une substance inhibant la prolifération cellulaire et/ou provoquant la mort cellulaire. Dans un mode de réalisation préféré, le stimulateur de la fonction du système immunitaire et/ou des cellules immunitaires sont des antagonistes de TGF-bêta sélectionnés dans le groupe des oligonucléotides s'hybridant avec une zone de l'ARN messager ou de l'ADN codant TGF-bêta, et la ou les substances inhibant la prolifération cellulaire et/ou provoquant la mort cellulaire sont sélectionnées dans le groupe des témozolomides, nitrosourées, alcaloïdes de la pervenche, antagonistes des bases purines et pyrimidines, antibiotiques actifs cytostatiques, dérivés de caphtotécine, anti-oestrogènes, anti-androgènes et analogues des gonadolibérines.

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