A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/20 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01) A61P 3/00 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2679416
The present invention relates to a combination therapy for the treatment of cardiovascular disorders. More particularly, the invention relates to compositions combining long-chain optionally substituted amphipatic carboxylates (known as MEDICA drugs) and particularly, M16.alpha..alpha., M16.beta..beta. and M18.gamma..gamma., with HMG-CoA reductase inhibitors (known as statins). The compositions of the invention may particularly be used for the treatment of cardiovascular disorders, for elevating HDL-cholesterol levels, decreasing non-HDL-cholesterol and particularly triglycerides, and decreasing insulin resistance in a subject suffering from Metabolic Syndrom or cardiovascular disorders. The invention further provides methods of treatment of such disorders using these combined compositions.
La présente invention concerne une polythérapie destinée au traitement de troubles cardiovasculaires. L'invention concerne plus particulièrement des compositions combinant des carboxylates amphipathiques à chaîne longue éventuellement substitués (autrement appelés médicaments MEDICA), notamment M16.alpha..alpha., M16.beta..beta. et M18.gamma..gamma., et des inhibiteurs de la HMG-CoA réductase (autrement appelés statines). Les compositions de l'invention peuvent être utilisées, en particulier pour le traitement de troubles cardiovasculaires, en vue d'augmenter les taux du cholestérol HDL, de baisser les taux du cholestérol non-HDL, notamment les triglycérides, et de diminuer la résistance à l'insuline chez un sujet souffrant du syndrome métabolique ou de troubles cardiovasculaires. L'invention concerne en outre des méthodes de traitement de tels troubles au moyen de ces compositions combinées.
Smart & Biggar
Syndromex Ltd.
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