Combination therapy employing ileal bile acid transport...

Details Combination therapy employing ileal bile acid transport... Combination therapy employing ileal bile acid transport...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/405 (2006.01)

Patent

CA 2283575

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.

La présente invention concerne des benzothiépines, certains de leurs dérivés et de leurs analogues. L'invention concerne également des compositions contenant ces benzothiépines, dérivés et analogues. L'invention concerne enfin des procédés permettant d'utiliser ces composés et compositions dans des médicaments, en particulier pour la prophylaxie et le traitement d'états hyperlipidémiques tels que ceux qui sont liés chez les mammifères à l'athérosclérose ou l'hypercholestérolémie. L'invention concerne en outre des compositions et des procédés applicables dans un traitement associé utilisant des benzothiépines inhibitrices du transport iléal de l'acide biliaire et des inhibiteurs de la HMG Co-A réductase pour le traitement d'états hyperlipidémique.

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