Combination therapy for glaucoma

Details Combination therapy for glaucoma Combination therapy for glaucoma

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61P 27/06 (2006.01)

Patent

CA 2721749

Disclosed herein is method of treating glaucoma or ocular hypertension comprising administering a prostaglandin agonist and a second therapeutically active agent to a mammal in need thereof, wherein said second therapeutically active agent is selected from: .beta.-Blockers, Adrenergic Agonists, non-selective adrenergic agonists, .alpha.2-selective adrenergic agonists, Carbonic Anhydrase Inhibitors, Cholinergic Agonists,direct acting cholinergic agonists, chlolinesterase inhibitors, Glutamate Antagonists, Ca2+ channel blockers, Prostamides, Prostaglandins, Cannabinoids, and combinations thereof. Compositions and medicaments containing a combination of these two active agents are also disclosed.

Cette invention concerne une méthode de traitement du glaucome ou de lhypertension oculaire comprenant ladministration dun agoniste des prostaglandines et un second agent thérapeutiquement actif chez un mammifère, ledit second agent thérapeutiquement actif étant choisi parmi les ß-bloquants, les agonistes adrénergiques, les agonistes adrénergiques non sélectifs, les agonistes adrénergiques a2-sélectifs, les inhibiteurs de lanhydrase carbonique, les agonistes cholinergiques, les agonistes cholinergiques à action directe, les inhibiteurs de cholinestérase, les agonistes du glutamate, les bloqueurs des canaux calciques, les prostamides, les prostaglandines, les cannabinoïdes et leurs associations. Linvention concerne également des compositions et des médicaments contenant une association de ces deux agents actifs.

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