Combination therapy for hiv infection

Details Combination therapy for hiv infection Combination therapy for hiv infection

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 31/165 (2006.01) A61K 31/55 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2193221

The combination of the HIV protease inhibitor Compound J and one or more of nevarapine or an .alpha.-APA derivative is useful in theinhibition of HIV protease, the inhibition of HIV reverse transcriptase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

La combinaison du composé J inhibiteur de VIH-protéase et de la névarapine et/ou d'un dérivé d'.alpha.-APA est utile pour inhiber la VIH-protéase, pour inhiber la VIH-transcriptase inverse, pour prévenir ou traiter les infections par le VIH et pour traiter le SIDA, cette combinaison se présentant sous la forme de composés, de sels pharmaceutiquement acceptables ou d'ingrédients de compositions pharmaceutiques associées ou non à d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins. Des procédés pour traiter le SIDA et des procédés pour prévenir ou traiter les infections à VIH sont également décrits.

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