Combination therapy for the treatment of aids

Details Combination therapy for the treatment of aids Combination therapy for the treatment of aids

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 31/52 (2006.01) A61K 31/535 (2006.01) A61K 38/06 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2309164

The combination of the HIV protease inhibitor Compound A and one or more nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, or protease inhibitors is useful in the inhibition of HIV protease, the inhibition of HIV reverse transcriptase, the prevention or treatment of AIDS, either as compounds, pharmaceutically acceptable salts or esters, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

L'association du composé A, un inhibiteur de la protéase du VIH, et d'un ou plusieurs inhibiteurs de la transcriptase inverse nucléosidique, d'inhibiteurs de la transcriptase inverse non nucléosidique ou d'inhibiteurs de la protéase, est utile pour inhiber la protéase du VIH ou la transcriptase inverse du VIH, et donc pour prévenir ou pour traiter le sida. Cette association peut être administrée sous forme de composés, de sels ou d'esters pharmaceutiquement acceptables, de principes actifs de compositions pharmaceutiques, et être associée ou non à d'autres antiviraux, à des immunomodulateurs, à des antibiotiques ou à des vaccins. L'invention concerne également des méthodes permettant de prévenir ou de traiter l'infection par le VIH.

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