Combination therapy for the treatment of bacterial infections

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/155 (2006.01) A01N 43/80 (2006.01) A01N 47/44 (2006.01) A01P 1/00 (2006.01) A61K 31/4174 (2006.01) A61K 31/43 (2006.01) A61K 31/496 (2006.01) A61K 31/635 (2006.01) A61K 31/7036 (2006.01) A61K 38/14 (2006.01) A61L 2/16 (2006.01) A61L 15/46 (2006.01) A61L 15/64 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01) A61L 29/16 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) C08L 101/02 (2006.01) C08L 101/16 (2006.01)

Patent

CA 2720721

Compositions comprising the combination of a membrane active biocide and a second agent selected from fluoro-quinolones, ammoglycodies, .beta.-lactams, glycopeptide antibiotics, sufonamides and antifungal azoles and their use in the treatment or prevention of bacterial or fungal infections Preferred membrane active biocides are selected from chlorohexidme, polymyxin B--nonapeptide, bacitracin, aztreonam, benzlakomum salts and metal chelators The active ingredients can be in either monomer or polymeric form.

La présente invention concerne des compositions comprenant la combinaison dun biocide à activité membranaire et un second agent choisi dans le groupe constitué des fluoroquinolones, des ammoglycodies, des ß-lactames, des antibiotiques glycopeptides, des sulfonamides et des azoles antifongiques et leur utilisation dans le traitement ou la prévention des infections bactériennes ou fongiques. Les biocides à activité membranaire préférés seront choisis dans le groupe constitué de la chlorohexidine, de la polymyxine B-nonapeptide, de la bacitracine, de laztréoname, des sels de benzlakomum et des chélateurs métalliques. Les ingrédients actifs peuvent se présenter sous forme de monomère ou de polymère.

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