Combination therapy for the treatment of cancer

Details Combination therapy for the treatment of cancer Combination therapy for the treatment of cancer

A - Human Necessities

61

K

A61K 51/10 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/336 (2006.01) A61K 31/4406 (2006.01) A61N 5/10 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2482508

The present invention relates to a method for the treatment of cancer in a patient in need thereof. The method comprises administering to a patient in need thereof a first amount of a histone deacetylase inhibitor in a first treatment procedure, and a second amount or dose of radiation in a second treatment procedure. The first and second treatments together comprise a therapeutically effective amount. The combination of the HDAC inhibitor and radiation therapy is therapeutically synergistic.

La présente invention concerne une méthode de traitement de cancer chez un patient le nécessitant. Cette méthode consiste à administrer au patient une première quantité d'un inhibiteur de l'histone-déacétylase au cours d'une première étape du traitement, et, puis, une seconde quantité ou une dose de rayonnements dans une seconde étape du traitement. Les premier et second traitements comprennent une quantité efficace thérapeutiquement. La combinaison de l'inhibiteur d'histone-déacétylase (HDAC) et de la radiothérapie a un effet synergique au niveau thérapeutique.

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