Combination therapy for the treatment of conditions with...

A - Human Necessities – 61 – K

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A61K 31/4164 (2006.01) A61K 31/42 (2006.01) A61K 31/519 (2006.01) A61K 31/56 (2006.01) A61K 31/60 (2006.01) A61K 33/24 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2480082

Compositions and methods for treating diseases that are associated with inflammation are provided. Such diseases include arthritis (particularly rheumatoid arthritis) and other autoimmune disorders, asthma, cardio-and cerebrovascular disease, burns, psoriasis, reperfusion injury, and traumatic CNS and spinal cord injury. The compositions generally comprise at least one C5a antagonist and at least one C5a receptor-inactive therapeutic agent. The methods involve co-administration of at least one C5a antagonist and at least one C5a receptor-inactive therapeutic agent to a patient. The C5a antagonist and C5a receptor-inactive therapeutic agent may be present within the same composition, or may be administered separately to the patient.

L'invention concerne des compositions et des méthodes de traitement de maladies associées à une inflammation, notamment l'arthrite (plus particulièrement la polyarthrite rhumatoïde) et d'autres troubles auto-immuns, l'asthme, les maladies cardio et cérébrovasculaires, les brûlures, la psoriasis, les lésions causées par la reperfusion, et les lésions traumatiques du système nerveux central et de la moelle épinière. Les compositions renferment généralement au moins un antagoniste C5a et au moins un agent thérapeutique à inactivité du récepteur C5a. Les méthodes consistent à co-administrer au moins un antagoniste C5a et au moins un agent thérapeutique d'inactivité du récepteur C5a à un patient. L'antagoniste C5a et l'agent thérapeutique d'inactivité du récepteur C5a peuvent être présents dans la même composition ou être administrés séparément au patient.

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