Combination therapy for the treatment of diabetes and...

Details Combination therapy for the treatment of diabetes and... Combination therapy for the treatment of diabetes and...

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/401 (2006.01) A61K 31/415 (2006.01) A61K 31/4196 (2006.01) A61P 3/00 (2006.01) A61P 3/10 (2006.01) C12N 15/12 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2593427

The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.

La présente invention concerne une combinaison composée d'une dose d'un agoniste GPR119 et d'une dose d'un inhibiteur de la dipeptidyl peptidase IV (DPP-IV), permettant de réduire la glycémie ou d'augmenter le taux de GLP-1 dans le sang plus efficacement chez un patient que si l'agoniste et l'inhibiteur étaient utilisés seuls. L'invention concerne également l'utilisation de cette combinaison pour le traitement ou la prévention du diabète et de troubles liés au diabète ou de troubles pouvant être soignés par augmentation du taux de GLP-1 dans le sang. La présente invention concerne également l'utilisation d'un récepteur couplé aux protéines G pour le criblage de secretagogues GLP-1.

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