G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) C07K 14/605 (2006.01) C07K 14/705 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2654733
The present invention provides methods for identification of Glucagon-like Peptide-1 (GLP-1) secretagogues which comprise determining whether a test compound has the activity of a G protein-coupled receptor 119 (GPR119) agonist. Such methods may also comprise determining whether a GPR119 agonist stimulates GLP-1 secretion. Also provided are methods for formulating compositions for stimulating GLP-1 secretion from compounds identified by the methods of this invention.
La présente invention porte sur des méthodes permettant de rechercher des sécrétagogues du GLP-1 (Glucagon-like Peptide-1), lesquelles permettent notamment de déterminer si un composé testé présente l'activité d'un agoniste du récepteur couplé à une protéine G 119 (GPR119). Ces méthodes peuvent également permettre de déterminer si un agoniste du GPR119 stimule la sécrétion du GLP-1. Aussi, l'invention concerne des méthodes permettant de préparer des compositions destinées à stimuler la sécrétion de GLP-1 à partir des composés trouvés par les méthodes de cette invention.
Al-Shamma Hussein
Chu Zhi-Liang
Jones Robert M.
Leonard James N.
Arena Pharmaceuticals Inc.
Smart & Biggar
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