Combination therapy for the treatment of diabetes and obesity

Details Combination therapy for the treatment of diabetes and obesity Combination therapy for the treatment of diabetes and obesity

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 31/24 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61K 38/22 (2006.01) A61K 45/06 (2006.01) C07K 14/575 (2006.01)

Patent

CA 2269660

The combination of a metabolic rate modifying agent (e.g., a .beta.3 adrenergic receptor agonist) and a feeding behavior modifying agent (e.g., a NPY5 antagonist) is useful in the treatment of obesity and diabetes, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients. Methods of treating obesity and diabetes are also described.

Selon l'invention, on utilise, pour le traitement de l'obésité et du diabète, une combinaison comprenant un agent modifiant la vitesse de métabolisme (par exemple un agoniste du récepteur adrénergique beta 3) et un agent modifiant le comportement alimentaire (par exemple un antagoniste du neuropeptide y5), se présentant sous la forme de composés, de sels pharmaceutiquement acceptables, ou d'ingrédients de compositions pharmaceutiques. L'invention concerne également des procédés de traitement de l'obésité et du diabète.

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