Combination therapy for the treatment of estrogen sensitive...

Details Combination therapy for the treatment of estrogen sensitive... Combination therapy for the treatment of estrogen sensitive...

A - Human Necessities

61

K

A61K 38/31 (2006.01) A61K 31/56 (2006.01) A61K 31/57 (2006.01) A61K 31/575 (2006.01) A61K 38/04 (2006.01) A61K 38/09 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2050291

Treatment of breast and endometrial cancer in susceptible warm blooded animals may include inhibition of ovarian hormonal secretion by surgical (ovariectomy) or chemical (use of an LHRH agonist, e.g. [D-Trp6, des-Gly-NH2 10]LHRH ethylamide or antagonist) as part of a combination therapy, and comprises use of an antiestrogen together with at least one compound selected from the group consisting of an androgenic compound and an inhibitor of an enzyme that catalyzes a step in the synthesis of sex steroids from sex steroid precursors in peripheral tissues, the inhibitor achieving that result by a non-adrenal mechanism. Pharmaceutical compositions useful for such treatment and pharmaceutical kits containing such compositions are disclosed.

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