A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4439 (2006.01) A61K 31/135 (2006.01) A61K 31/4015 (2006.01) A61K 31/4035 (2006.01) A61K 31/517 (2006.01) A61K 31/58 (2006.01) A61K 31/635 (2006.01) A61P 13/02 (2006.01)
Patent
CA 2681749
This invention concerns compositions for the treatment of Lower Urinary Tract Symptoms (LUTS), and especially LUTS which results from benign prostatic hypertrophy. The compositions of the invention comprise a Beta-3 agonist described below, optionally in combination with a 5-alpha reductase inhibitor, or an NK-1 antagonist or an alpha-1 adrenergic antagonist or an anti-muscarinic agent. The invention also includes compositions comprising a beta-3 agonist and two additional active agents selected from a 5-alpha reductase inhibitor, an NK-1 antagonist, an alpha-1 adrenergic antagonist or an anti-muscarinic agent.
L'invention concerne des compositions pour le traitement de troubles urinaires du bas appareil (TUBA), et notamment de TUBA qui résultent d'une hypertrophie prostatique bégnine. Les compositions de l'invention comprennent un agoniste Bêta-3 décrit ci-après, éventuellement combiné à un inhibiteur de la 5-alpha réductase, ou à un antagoniste du récepteur NK-1 ou à un antagoniste alpha-1 adrénergique ou à un agent anti-muscarinique. L'invention concerne également des compositions comprenant un agoniste bêta-3 et deux agents actifs additionnels sélectionnés parmi un inhibiteur de la 5-alpha réductase, un antagoniste du récepteur NK-1, un antagoniste alpha-1 adrénergique ou un agent anti-muscarinique.
Frenkl Tara
Green Stuart A.
Macintyre Euan
Mills Sander G.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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