Combination therapy for treating disease

Details Combination therapy for treating disease Combination therapy for treating disease

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2464947

Disclosed are methods for treating cancer comprising administering a xenotypic monoclonal antibody and a chemotherapeutic drug to a patient suffering from cancer. Also disclosed is a method for inducing a host immune response in a patient against a multi-epitopic in vivo tumor antigen in present in the host serum, which antigen does not elicit a host immune response, comprising administering to the patient a chemotherapeutic drug and a composition comprising a binding agent that specifically binds to a first epitope on the antigen and allowing the binding agent to form a binding agent/antigen pair, wherein a host immune response is elicited against a second epitope on the antigen.

L'invention concerne des procédés permettant de traiter le cancer, qui consistent à administrer à un patient souffrant du cancer un anticorps monoclonal xénotypique et un produit chimiothérapeutique. L'invention concerne également un procédé permettant d'induire une réponse immunitaire de l'hôte chez un patient contre un antigène tumoral in vivo à épitopes multiples présent dans le sérum de l'hôte, ledit antigène ne déclenchant pas une réponse immunitaire de l'hôte, qui consiste à administrer au patient un produit chimiothérapeutique et une composition comportant un liant qui se lie spécifiquement à un premier épitope sur l'antigène et à permettre au liant de former une paire agent de liaison/antigène, la réponse immunitaire d'hôte étant déclenchée contre un second épitope sur l'antigène.

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