A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2478338
The present invention relates to methods and compositions designed for the treatment, management or prevention of cancer. The methods of the invention comprise the administration of an effective amount of one or more inhibitors of JNK in combination with the administration of an effective amount of one or more other agents useful for cancer therapy. The invention also provides pharmaceutical compositions comprising one or more inhibitors of JNK in combination with one or more other agents useful for cancer therapy. In particular, the invention is directed to methods of treatment and prevention of cancer by the administration of an effective amount of one or more inhibitors of JNK in combination with standard and experimental chemotherapies, hormonal therapies, bone marrow transplants, stem cell replacement therapies, biological therapies/immunotherapies and/or radiation therapies for treatment or prevention of cancer. Also included are methods of treatment of cancer by the administration of one or more inhibitors of JNK in combination with surgery, alone or in further combination with standard and experimental chemotherapies, hormonal therapies, bone marrow transplants, stem cell replacement therapies, biological therapies/immunotherapies and/or radiation therapies.
L'invention concerne des procédés et des compositions conçus pour le traitement, la gestion ou la prévention du cancer. Les procédés de cette invention comprennent l'administration d'une quantité efficace d'un ou plusieurs inhibiteurs de la protéine JNK combinée à l'administration d'une quantité efficace d'un ou plusieurs autres agents utiles à la cancérothérapie. L'invention concerne également des compositions pharmaceutiques comprenant un ou plusieurs inhibiteurs de la protéine JNK combinés à un ou plusieurs autres agents utiles à la cancérothérapie. Plus spécifiquement, l'invention concerne des procédés de traitement et de prévention du cancer par administration d'une quantité efficace d'un ou plusieurs inhibiteurs de la protéine JNK combinée à des chimiothérapies, thérapies hormonales, transplantations de moelle osseuse, thérapie de substitution de cellules souches, thérapies biologiques/immunothérapies et/ou radiothérapies expérimentales et standard pour le traitement ou la prévention du cancer. L'invention concerne également des procédés de traitement du cancer par administration d'un ou plusieurs inhibiteurs de la protéine JNK combinée à la chirurgie seule ou combinée encore à des chimiothérapies, thérapies hormonales, transplantations de moelle osseuse, thérapies de substitution de cellules souches, thérapies biologiques/immunothérapies et/ou radiothérapies.
Ennis Bruce W.
Stein Bernd M.
Westwick John K.
Osler Hoskin & Harcourt Llp
Signal Pharmaceuticals Inc.
Signal Pharmaceuticals Llc
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