A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/541 (2006.01) A61K 31/4409 (2006.01) A61K 31/496 (2006.01) A61K 31/4965 (2006.01) A61P 31/06 (2006.01)
Patent
CA 2735229
The present invention relates to methods of treating tuberculosis, including multi~ drug resistant varieties and la-tent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising ad-ministering to said mammal in need thereof an effective amount of a compound of formula (I), (S)-N- [[3-[3-fluoro-4-(4-thiomor-pholinyl)phenyl]-2-oxo-5- oxazolidinyl]methyl]acetamide, or a pharmaceutically acceptable salt thereof in combination with at least two agents useful in the treatment of tuberculosis. The present invention also relates to a pharmaceutical composition com-prising a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, (ii) a therapeutically effective amount of at least one agent useful in the treatment of tuberculosis and (iii) one or more pharmaceu-tically acceptable carriers or vehicles.
La présente invention concerne des procédés de traitement de la tuberculose, comprenant des variétés multirésistantes aux médicaments et la tuberculose latente. Plus particulièrement, la présente invention concerne un procédé de traitement de la tuberculose chez un mammifère comprenant ladministration audit mammifère nécessitant celle-ci dune quantité efficace dun composé de formule (I), (S)-N-[[3-[3-fluoro-4-(4-thiomorpholinyl)phényl]-2-oxo-5-oxazolidinyl]méthyl]acétamide, ou un sel pharmaceutiquement acceptable de celui-ci en combinaison avec au moins deux agents utiles dans le traitement de la tuberculose. La présente invention concerne en outre une composition pharmaceutique comprenant une quantité thérapeutiquement efficace dun composé de formule (I) ou un sel pharmaceutiquement acceptable ou solvate de celui-ci, (ii) une quantité thérapeutiquement efficace dau moins un agent utile dans le traitement de la tuberculose et (iii) un ou plusieurs véhicules pharmaceutiquement acceptables.
Brickner Steven Joseph
Nuermberger Eric
Stover Charles Kendall
Pfizer Inc.
The Johns Hopkins University
Torys Llp
LandOfFree
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