C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/22 (2006.01) A61K 31/00 (2006.01) A61K 31/573 (2006.01) A61K 31/675 (2006.01) A61K 47/16 (2006.01)
Patent
CA 2451602
The present invention relates to pharmaceutical compositions and methods using such compositions for the treatment of inflammatory disease. Such compositions contain a catalyst for the dismutation of superoxide, including superoxide dismutase enzyme (SOD) and low molecular weight organic ligand derived metal complexes characterized in having the following structure: (Z)n that function as mimics of the enzyme (SOD mimetics or SODm) in combination with corticosteroids.
La présente invention concerne des compositions pharmaceutiques et des techniques utilisant ces compositions destinées au traitement de maladie inflammatoire. Ces compositions contiennent un catalyseur destiné à la dismutation du superoxyde, notamment de l'enzyme superoxyde-dismutase (SOD) et d'un ligand organique à faible poids moléculaire dérivé de complexes métalliques caractérisé par la structure suivante: (Z)¿n?, qui fonctionne comme un mimétique de cette enzyme (mimétique de SOD ou DODm) en combinaison avec des corticostéroïdes.
Mcfadden Fincham
Metaphore Pharmaceuticals Inc.
Pharmacia Corporation
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