A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/70 (2006.01) A61K 39/39 (2006.01) A61P 3/10 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2712404
The present invention relates to a combination therapy for the treatment of immune-related disorders. More particularly, the invention relates to oral or mucosal synergistic compositions combining beta-glycolipids, preferably, O-glycosphin-golipids with immunoglobulin molecules specific for at least one antigen derived from a component of the immune system, specifically an anti-CD3 antibody. The invention further provides methods kits and uses of the combined compositions of the invention for immuno- modulation and thereby for the treatment of immune-related disorders. In a preferred embodiment, anti-CD3 antibody (OKT3) is orally administered in combination with .beta.-glucosylceramide (also known as glycocerebroside) in an animal model of type 2 diabetes.
La présente invention concerne une polythérapie pour le traitement de troubles de nature immunitaire. Plus particulièrement, l'invention concerne des compositions synergiques administrées par voie orale ou muqueuse qui combinent des bêta-glycolipides, de préférence, des ß-glycosphingolipides, avec des molécules d'immunoglobuline spécifiques pour au moins un antigène dérivé d'un composant du système immunitaire, plus particulièrement un anticorps anti-CD3. L'invention concerne en outre des procédés, des kits et des utilisations des compositions combinées de l'invention pour une immunomodulation et ainsi pour le traitement de troubles de nature immunitaire.
Ilan Yaron
Weiner Howard L.
Hadasit Medical Research Services & Development Ltd.
Shapiro Cohen
The Brigham And Women's Hospital Inc.
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