Combination therapy related to serotonin dual action compounds

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/404 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) C07D 209/20 (2006.01) C07D 209/30 (2006.01)

Patent

CA 2700199

The present invention relates to combination therapies and pharmaceutical compositions comprising a combination of 5-hydroxytryptophan and a serotonin reuptake inhibitor that binds to an ailosteric site of the serotonin transporter. The present invention further provides a pharmaceutical composition comprising (i) 5- hydroxytryptophan in an amount ranging from about 1 mg to about 75 mg; and (ii) a serotonin reuptake inhibitor that binds to an allosteric site of the serotonin transporter.

La présente invention concerne des traitements combinés et des compositions pharmaceutiques comprenant une combinaison de 5-hydroxytryptophane et d'inhibiteur de la recapture de la sérotonine qui se lient à un site allostérique du transporteur de la sérotonine. La présente invention concerne en outre une composition pharmaceutique comprenant (i) du 5-hydroxytryptophane en une quantité de l'ordre d'environ 1 mg à environ 75 mg; et (ii) un inhibiteur de la recapture de la sérotonine qui se lie à un site allostérique du transporteur de la sérotonine.

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