A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/00 (2006.01) A61K 31/565 (2006.01) A61K 38/00 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2449166
The invention relates to a combination therapy for the treatment of tumors and tumor metastases, preferably breast and prostate tumors, comprising administration of anti-EGFR (Her1) antibodies and anti-hormonal agents, optionally together with cytotoxic / chemotherapeutic agent. The method and the pharmaceutical compositions comprising said agents can result in a synergistic potentiation of the tumor cell proliferation inhibition effect of each individual therapeutic agent, yielding more effective treatment than found by administering an individual component alone.
L'invention porte sur une thérapie combinée de traitement des tumeurs de préférence de la prostate et du sein et des métastases associées, consistant à administrer des anticorps anti-EGFR (Her1) et des agents anti-hormonaux facultativement en association avec un agent cytotoxique/chimiotherapeutique. Le procédé et les préparations pharmaceutiques contenant lesdits agents peuvent produire une potentialisation synergique de l'effet inhibiteur de la prolifération des cellules tumorales de chacun des agents séparés, constituant un traitement plus efficace que l'administration des composants isolés.
Harstrick Andreas
Rosen Oliver
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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