Combination therapy using nucleic acids and radio therapy

Details Combination therapy using nucleic acids and radio therapy Combination therapy using nucleic acids and radio therapy

C - Chemistry, Metallurgy

12

N

C12N 13/00 (2006.01) A61K 41/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2325596

The present invention relates to methods for increasing the efficiency of transformation of cycling cells, the methods comprising synchronizing cells at a first stage of the cell cycle, and transforming the cells at a second stage of the cell cycle within about one cell cycle of the first stage with a genetically engineered nucleic acid that encodes a desired gene product. The invention further relates to cancer therapy and, in particular, to methods of efficiently transforming cancer cells with nucleic acids that encode gene products that inhibit the growth of cancer cells.

La présente invention concerne des méthodes permettant d'améliorer l'efficacité de la transformation de cellules à cycle. Ces méthodes consistent à synchroniser des cellules dans un premier stade du cycle cellulaire, puis à transformer ces cellules dans un second stade du cycle cellulaire, en l'espace d'environ un cycle cellulaire du premier stade, avec un acide nucléique obtenu par génie génétique codant un produit génique voulu. L'invention concerne également une thérapie anticancéreuse et, en particulier, des méthodes permettant de transformer efficacement des cellules cancéreuses avec des acides nucléiques codant des produits géniques inhibant la croissance de cellules cancéreuses.

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