A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/517 (2006.01) A61K 31/13 (2006.01) A61K 31/14 (2006.01) A61K 31/36 (2006.01) A61K 31/395 (2006.01) A61K 31/4025 (2006.01) A61K 31/4168 (2006.01) A61K 31/417 (2006.01) A61K 31/475 (2006.01) A61K 31/505 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2355411
Methods are provided for preventing or inhibiting adverse cardiovascular effects associated with administration of a sympathetic nervous system antagonist in a subject, in which a subject in need thereof is administered a sympathetic nervous system antagonist and an endothelin antagonist. Methods of treating hypertension in a subject are also provided, in which a subject in need thereof is administered a sympathetic nervous system antagonist and an endothelin antagonist. Methods for improving the efficacy of a sympathetic nervous system antagonist are also provided, comprising administering to a subject in need thereof a sympathetic nervous system antagonist together with an endothelin antagonist. Methods of treating prostate cancer or benign prostate hyperplasia (BPH) in a subject are also provided, in w hich a subject in need thereof is administered a sympathetic nervous system antagonist and an endothelin antagonist. The sympathetic nervous system antagonist may be an alpha- adrenoceptor antagonist, a ganglionic blocking agent or another inhibitor of the actions of the sympathetic nervous system.
Adams Michael A.
Bridge Suzanne K.
Heaton Jeremy P.w.
Queen's University At Kingston
Scribner Stephen J.
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