Combination therapy using trefoil peptides

Details Combination therapy using trefoil peptides Combination therapy using trefoil peptides

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2480372

This invention features methods and compositions of combination therapy suitable for treating and preventing epithelial lesions. Lesions are treated or prevented by combining trefoil peptide therapy with another medically useful therapeutic agent. Suitable therapeutics for combination therapy with a trefoil peptide included chemotherapeutics, particularly orally administered chemotherapeutics, analgesic, antibiotic, and anti-inflammatory agents. Useful trefoil peptides include the naturally occurring trefoil peptides intestinal trefoil factor, spasmolytic polypeptide (SP), and pS2, as well as non- naturally occurring peptides that contain a trefoil domain.

L'invention concerne des méthodes et des compositions de thérapie de combinaison appropriées permettant de traiter et de prévenir des lésions épithéliales. Ces lésions sont traitées ou prévenues par combinaison d'une thérapie utilisant des peptides en feuille de trèfle et d'un autre agent thérapeutique médicalement utile. Les agents thérapeutiques appropriés pour une thérapie de combinaison utilisant des peptides en feuille de trèfle comprennent des agents chimiothérapeutiques, lesdits agents étant notamment administrés oralement, et des agents analgésiques, antibiotiques et anti-inflammatoires. Les peptides en feuille de trèfle utiles comprennent les peptides en feuille de trèfle naturels, un facteur intestinal en feuille de trèfle, un polypeptide spasmolytique (SP) et pS2, ainsi que des peptides non naturels contenant un domaine en feuille de trèfle.

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