Combination therapy wherein a serotonin reuptake inhibitor...

A - Human Necessities – 61 – K

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A61K 31/662 (2006.01) A61K 31/185 (2006.01) A61K 31/343 (2006.01) A61K 31/4741 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2490638

The invention relates to the use of a compound, which is a serotonin reuptake inhibitor, and another compound, which is a GABAB receptor antagonist, inverse agonist or partial agonist for the preparation of a pharmaceutical composition for the treatment of depression, anxiety disorders and other affective disorders, such as generalized anxiety disorder, panic anxiety, obsessive compulsive disorder, acute stress disorder, post traumatic stress disorder and social anxiety disorder, eating disorders such as bulimia, anorexia and obesity, phobias, dysthymia, premenstrual syndrome, cognitive disorders, impulse control disorders, attention deficit hyperactivity disorder, drug abuse or any other disorder responsive to serotonin reuptake inhibitors.

L'invention concerne l'utilisation d'un composé, qui est un inhibiteur du recaptage de la sérotonine, et d'un autre composé, qui est un antagoniste du récepteur GABA<SB>B</SB>, un agoniste inverse ou un agoniste partiel, pour la préparation d'une composition pharmaceutique destinée au traitement de la dépression, de troubles de l'anxiété et d'autres troubles affectifs, tels que les troubles de l'anxiété généralisée, l'anxiété panique, les troubles obsessionnels compulsifs, les troubles liés au stress aigu, les troubles de stress post-traumatique et les troubles de l'anxiété sociale, des troubles de l'alimentation tels que la boulimie, l'anorexie et l'obésité, les phobies, la dysthymie, le syndrome prémenstruel, les troubles cognitifs, les troubles du contrôle des impulsions, les troubles de l'hyperactivité avec déficit de l'attention, l'abus de médicaments ou n'importe quels autres troubles sensibles aux inhibiteurs du recaptage de la sérotonine.

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