Combination therapy with gemcitabine and zd6126

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/661 (2006.01) A61K 31/7068 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2500906

The present invention relates to a method for the production of a vascular damaging effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation, particularly a method for the treatment of a cancer involving a solid tumour, which comprises the administration of ZD6126 in combination with gemcitabine; to a pharmaceutical composition comprising ZD6126 and gemcitabine; to a combination product comprising ZD6126 and gemcitabine for use in a method of treatment of a human or animal body by therapy; to a kit comprising ZD6126 and gemcitabine; and to the use of ZD6126 and gemcitabine in the manufacture of a medicament for use in the production of a vascular damaging effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation.

L'invention se rapporte à une méthode de production d'un effet d'endommagement vasculaire chez un animal à sang chaud, tel qu'un être humain, qui est éventuellement traité par rayonnement ionisant, en particulier à une méthode de traitement d'un cancer comprenant une tumeur solide, qui consiste notamment à administrer ZD6126 combiné à gemcitabine. L'invention se rapporte en outre à une composition pharmaceutique comprenant ZD6126 et gemcitabine; à un produit de combinaison comprenant ZD6126 et gemcitabine à utiliser dans une méthode de traitement du corps d'un être humain ou d'un animal par thérapie; à une trousse comprenant ZD6126 et gemcitabine; et à l'utilisation de ZD6126 et de gemcitabine dans la production d'un médicament à utiliser dans la production d'un effet d'endommagement vasculaire chez un animal à sang chaud, tel qu'un être humain, qui est éventuellement traité par rayonnement ionisant.

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