Combination therapy with thiocolchicine derivatives

Details Combination therapy with thiocolchicine derivatives Combination therapy with thiocolchicine derivatives

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 9/14 (2006.01) A61K 31/165 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2755121

The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising administering to an individual an effective amount of a colchicine or thiocolchicine dimer and an anti-VEGF antibody. The method may further comprise administering an effective amount of a taxane. The colchicine or thiocolchicine dimer and the taxane (such as paclitaxel) may be present in the form of nanoparticles, such as nanoparticles comprising the drug and a carrier protein such as albumin.

La présente invention porte sur des méthodes de polythérapie consistant à traiter une maladie proliférative (telle que le cancer) comprenant l'administration à un individu d'une quantité efficace d'une colchicine ou d'un dimère de thiocolchicine et d'un anticorps anti-VEGF. La méthode peut en outre comprendre l'administration d'une quantité efficace d'un taxane. La colchicine ou le dimère de thiocolchicine et le taxane (tel que le paclitaxel) peuvent être présents sous la forme de nanoparticules, telles que des nanoparticules comprenant le médicament et une protéine de support telle que l'albumine.

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