A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/7076 (2006.01) A61P 37/06 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2590471
This invention is directed towards treatments for multiple sclerosis comprising administering to a patient in need thereof a first agent, such as 2- chloro-2'-deoxyadenosine (2-CdA), that reduces the number of lymphocytes in combination with a second agent, such as an anti-alpha-4 integrin antibody, that blocks the adhesion of monocytes and leukocytes to endothelial cells. The use of 2-CdA combined with an anti-alpha-4 integrin antibody may be more effective than either treatment alone for MS. Furthermore, the combination treatment may allow for a lowering or altering the dose of one or more of the agents in order to limit any adverse effects associated with the individual agents, but maintaining the same therapeutic efficacy.
La présente invention se rapporte à des traitements contre la sclérose en plaques comprenant l'administration à un patient nécessitant un tel traitement d'un premier agent, tel que la 2-chloro-2'-désoxyadénosine (2-CdA), qui réduit le nombre de lymphocytes, combiné à un deuxième agent, tel qu'un anticorps anti-alpha-4 intégrine, qui bloque l'adhésion de monocytes et de leucocytes à des cellules endothéliales. L'utilisation de 2-CdA combiné à un anticorps anti-alpha-4 intégrine peut être plus efficace que tout autre traitement utilisé seul contre la sclérose en plaques. De plus, la polythérapie peut permettre de réduire ou de modifier la dose d'un ou plusieurs agents afin que tout effet secondaire associé aux agents pris individuellement soit limité tout en permettant de conserver la même efficacité thérapeutique.
Kirby Eades Gale Baker
Laboratoires Serono S.a.
Merck Serono Sa
LandOfFree
Combination treatment for multiple sclerosis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combination treatment for multiple sclerosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combination treatment for multiple sclerosis will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1626497