A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/57 (2006.01) A61K 31/565 (2006.01)
Patent
CA 2140952
This invention provides a new method for treating osteoporosis comprising administering: 1) a compound of formula I Image (I) wherein R and R1, independently, are hydrogen, hydroxyl, C1-C6-alkoxy, C1-C6 acyloxy, C1-C6 alkoxy-C2-C6-acyloxy, R2-substituted aryloxy, R2-substituted aroyloxy, R3-substituted carbonyloxy or halo; R2 is C1-C3-alkyl, C1-C3-alkoxy, hydrogen or halo; and R3 is C1-C6-alkoxy or aryloxy; n is 2, 3 or 4; and p is 4, 5 or 6; or a pharmaceutically acceptable salt or solvate thereof; together with 2) a progestin selected from medroxyprogesterone, norethindrone or norethynodrel, or a pharmaceutically acceptable salt thereof; in amounts such that the combination retains or increases bone density. The invention also provides pharmaceutical formulations for inhibiting bone loss comprising (1) a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof; and (2) a progestin selected from medroxyprogesterone, norethindrone or norethynodrel, or a pharmaceutically acceptable salt thereof; in amounts such that the combination inhibits bone loss, together with one or more pharmaceutically acceptable carriers.
Black Larry John
Cullinan George Joseph
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
Combination treatment for osteoporosis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combination treatment for osteoporosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combination treatment for osteoporosis will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1494677