Combination treatment of obesity involving selective...

Details Combination treatment of obesity involving selective... Combination treatment of obesity involving selective...

A - Human Necessities

61

K

A61K 31/454 (2006.01) A61K 31/05 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/343 (2006.01) A61K 31/352 (2006.01) A61K 31/353 (2006.01) A61K 31/365 (2006.01) A61K 31/397 (2006.01) A61K 31/4164 (2006.01) A61K 31/4166 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61K 31/5355 (2006.01) A61K 31/785 (2006.01)

Patent

CA 2543197

The present invention relates to a novel medical use of selective CB1 receptor antagonistic compounds in combination with lipase inhibitors. Said compounds are particularly suitable in combination with lipase inhibitors in the manufacture of medicaments for the treatment and/or prophylaxis of obesity in adolescent or in juvenile patients and/or for the treatment and/or prophylaxis of drug induced obesity in juvenile as well as in adolescent patients. The CB1 receptor antagonistic compounds suitable according to the invention are elucidated in more detail in the description. Preferred lipase inhibitors are orlistat, panclicins, ATL-962 and/or lipstatin.

La présente invention concerne une nouvelle utilisation médicale des composés antagonistes sélectifs des récepteurs du CB¿1? combinés à des inhibiteurs de lipase. Lesdits composés sont particulièrement adaptés lorsque combinés aux inhibiteurs de lipase dans la fabrication de médicaments utilisés dans le traitement et/ou la prophylaxie de l'obésité chez les patients adolescents ou juvéniles et/ou dans le traitement et/ou la prophylaxie de l'obésité induite par les médicaments chez des patients juvéniles et adolescents. Les composés antagonistes des récepteurs du CB¿1? adaptés selon la présente invention sont étudiés de manière plus détaillée dans la description. Les inhibiteurs de lipase préférés sont l'orlistat, les panclicines, ATL-962 et/ou la lipstatine.

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