Combination treatments for alzheimer's disease and related...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61K 31/047 (2006.01) A61P 25/28 (2006.01) C07C 35/14 (2006.01) C07C 35/16 (2006.01) C12N 9/64 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2670405

The invention relates generally to novel compositions and methods comprising a cyclohexanehexol and a secretase inhibitor The compositions and methods provide beneficial effects, in particular sustained beneficial effects, in the treatment of diseases involving a disorder in protein folding and/or aggregation, and/or amyloid formation, deposition, accumulation, or persistence, such as Alzheimer's disease and related neurodegenerative disorders.

L'invention porte d'une manière générale sur de nouvelles compositions et de nouveaux procédés comprenant un cyclohexanehexol et un inhibiteur de la sécrétase. Les compositions et procédés fournissent des effets utiles, en particulier, des effets utiles entretenus, dans le traitement de maladies mettant en jeu un trouble dans le repliement et/ou l'agrégation de protéines, et/ou la formation, le dépôt, l'accumulation ou la persistance d'amyloïdes, telles que la maladie d'Alzheimer et des troubles neurodégénératifs apparentés.

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