Combination treatments for chemokine-mediated diseases

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 413/12 (2006.01) A61K 31/381 (2006.01) A61K 31/422 (2006.01) A61K 31/4402 (2006.01) A61K 45/06 (2006.01) A61P 1/00 (2006.01) A61P 3/00 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2479126

88thods of treating chemokine-mediated diseases are disclosed. The methods comprise the administration of CXC-Chemokine receptor antagonists of the formula (Chemical formula should be inserted here as it appears on abstract in paper form) ,or pharmaceutically acceptable salts or solvates thereof, in combination with other classes of pharmaceutical compounds. The chemokine- mediated diseases include acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, asthma and cancer. Also disclosed are novel compounds of formula (I).

L'invention concerne des méthodes de traitement de maladies induites par la chimiokine. Ces méthodes consistent à administrer des antagonistes du récepteur de la chimiokine CXC de formule (I), ou des sels ou solvates pharmaceutiquement acceptables desdits composés, en combinaison avec d'autres classes de composés pharmaceutiques. Les maladies induites par la chimiokine comprennent les troubles inflammatoires aigus et chroniques, le psoriasis, la mucoviscidose, l'asthme et le cancer. L'invention concerne également des nouveaux composés de formule (I).

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