Combination viral-based and gene-based therapy of tumors

Details Combination viral-based and gene-based therapy of tumors Combination viral-based and gene-based therapy of tumors

A - Human Necessities

61

K

A61K 35/00 (2006.01) A61K 35/76 (2006.01) A61K 47/48 (2006.01) C12N 7/00 (2006.01) C12N 15/63 (2006.01) C12N 15/869 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2327506

The present invention relates to viral mutants and methods of using these viral mutants for selectively killing neoplastic cells. The viral mutants of the invention are capable of selectively killing neoplastic cells by a combination of viral mediated oncolysis and anti-cancer ("suicide") gene therapy.

L'invention se rapporte aux mutants viraux et aux procédés de leur utilisation pour tuer de façon sélective des cellules néoplasiques. Les mutants viraux de cette invention peuvent tuer de façon sélective des cellules néoplasiques grâce à une combinaison de la destruction tumorale à médiation virale et de la thérapie anticancéreuse aux gènes-suicide.

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