A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/58 (2006.01) A61K 38/16 (2006.01) A61K 38/49 (2006.01)
Patent
CA 2064231
2064231 9101142 PCTABS00003 The present invention relates to combinations and methods which are effective in thrombolytic therapy and prophylaxis. More particularly, this invention relates to pharmaceutically effective combinations of a) a peptide which is homologous to at least a portion of the carboxyl terminal 25 amino acids of hirudin, or a derivative thereof, which displays anticoagulant activity ("anticoagulant peptide" or "hirudin peptide"); and b) a thrombolytic agent for treating or preventing thrombotic diseases. This invention also relates to methods for decreasing reperfusion time, or increasing reocclusion time, or both, in a patient treated with a thrombolytic agent by administering to the patient a combination of a thrombolytic agent and an anticoagulant peptide. And the invention relates to methods for decreasing the dosage of a thrombolytic agent required for a desired therapeutic or prophylatic effect in a patient, such as to dissolve a blood clot, by administering to the patient a combination of an anticoagulant peptide and a thrombolytic agent, the dosage of the thrombolytic agent being less thanthat required for a desired therapeutic or prophylactic effect when that agent is administered as a monotherapy.
Biogen Inc.
Maraganore John M.
Smart & Biggar
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