Combinations comprising a cdk inhibitor and a growth factor...

Details Combinations comprising a cdk inhibitor and a growth factor... Combinations comprising a cdk inhibitor and a growth factor...

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 31/337 (2006.01) A61K 31/55 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2623729

The present invention provides a combination comprising a compound A of formula (I) as set forth in the specification or a pharmaceutically acceptable salt thereof, and an antibody inhibiting a growth factor or its receptor and/or an antimitotic agent or a derivative or prodrug thereof, useful in the treatment of tumors. The chemical name of compound A is 8-[4-(4-methyl- piperazin-1-yl)- phenylamino]-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3- h]quinazoline-3-carboxylic acid methylamide.

La présente invention concerne une combinaison, comprenant un composé A de formule (I) telle que présentée dans la description, ou un de ses sels pharmaceutiquement acceptables, et un anticorps inhibant un facteur de croissance ou son récepteur, et/ou un agent antimitotique ou un dérivé ou promédicament de cet agent, qui est utile dans le traitement de tumeurs. Le nom chimique du composé A est méthylamide d'acide 8-[4-(4-méthylpipérazin-1-yl)phénylamino]-1,4,4-triméthyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylique.

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