Combinations comprising a selective cyclooxygenase-2 inhibitor

A - Human Necessities – 61 – K

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A61K 31/196 (2006.01) A61K 31/195 (2006.01) A61K 31/50 (2006.01) A61K 31/502 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2464309

A combination therapy for treating patients suffering from pre-malignant colon lesions (e.g. polyps) and colon cancer, as well as other malignancies, is disclosed. The patient is treated concurrently with a cycloocygenase-2 inhibitor and at least one compound selected from the group consisting of a microtubule interfering agent, an epithelial growth factor receptor tyrosine protein kinase inhibitor and a vascular endothelial growth factor receptor tyrosine kinase inhibitor.

La présente invention concerne un thérapie combinatoire destinée à traiter des patients souffrant de lésions précancéreuses du côlon (par exemple, de polypes), de cancers du côlon et d'autres tumeurs cancéreuses. Selon l'invention, on traite le patient simultanément avec un inhibiteur de la cyclooxygénase-2 et au moins un composé choisi dans le groupe composé d'un agent interférant avec les microtubules, d'un inhibiteur des protéines tyrosine kinases du récepteur du facteur de croissance épithéliale et d'un inhibiteur des protéines tyrosine kinases du récepteur du facteur de croissance endothéliale vasculaire.

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