Combinations comprising alpha-2-delta ligands and serotonin...

Details Combinations comprising alpha-2-delta ligands and serotonin... Combinations comprising alpha-2-delta ligands and serotonin...

A - Human Necessities

61

K

A61K 31/5375 (2006.01) A61K 31/195 (2006.01) A61K 31/197 (2006.01) A61K 31/41 (2006.01) A61P 25/02 (2006.01) A61P 25/04 (2006.01) A61P 25/06 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2537402

The instant invention relates to a combination, particularly a synergistic combination, of an alpha-2-delta ligand and a dual serotonin-noradrenaline re- uptake inhibitor (DSNRI) or one or both of a selective serotonin re-uptake inhibitor (S SRI) and a selective noradrenaline re-uptake inhibitor (SNRI), and pharmaceutically acceptable salths thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly neuropathic pain.

L'invention concerne une association, en particulier une association synergique, d'un ligand alpha-2-delta et d'un inhibiteur double du recaptage de la sérotonine et de la noradrénaline (DSNRI) ou d'un inhibiteur sélectif du recaptage de la sérotonine (SSRI) et/ou d'un inhibiteur sélectif du recaptage de la noradrénaline (SNRI), ainsi que leurs sels pharmaceutiquement acceptables, des compositions pharmaceutiques les contenant et leur utilisation pour le traitement de la douleur, en particulier la névropathie.

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