Combinations comprising ampa receptor antagonists for the...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/675 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2541293

The present invention relates to combinations suitable for the treatment of psychiatric/neurological disorders, in particular schizophrenia. The combinations comprise at least one AMPA receptor antagonist and at least one compound selected from the group consisting of (a) anti-epileptic drugs selected from barbiturates and derivatives thereof, benzodiazepines, carboxamides, hydantoins, succinimides, valproic acid and other fatty acid derivates and other anti-epileptic drugs, (b) conventional antipsychotics and (c) atypical antipsychotics.

L'invention concerne des combinaisons appropriées pour traiter des troubles psychiatriques/neurologiques, notamment la schizophrénie. Lesdites combinaisons comprennent au moins une antagoniste du récepteur AMPA et au moins un composé sélectionné dans le groupe comprenant : (a) des médicaments anti-épileptiques, sélectionnés parmi des barbiturates et leurs dérivés, des benzodiazépines, des carboxamides, des hydantoïnes, des succinimides, de l'acide valproïque, d'autres dérivés d'acide gras et d'autres médicaments anti-épileptiques, (b) des antipsychotiques classiques et (c) des antipsychotiques atypiques.

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