Combinations comprising antimuscarinic agents and...

A - Human Necessities – 61 – K

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A61K 31/4995 (2006.01) A61K 31/138 (2006.01) A61K 31/167 (2006.01) A61K 45/06 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01)

Patent

CA 2533061

A combination which comprises (a) a .beta.2 agonist and (b) an antagonist of M3 muscarinic receptors which is 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3- phenoxypropyl)-1-azoniabicyclo[2.2.2]octane, in the form of a salt having an anion X, which is a pharmaceutically acceptable anion of a mono or polyvalent acid.

La présente invention concerne une combinaison comprenant (a) un agoniste .beta.2 et (b) un antagoniste des récepteurs muscariniques M3, lequel est représenté par 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane, sous la forme d'un sel présentant un anion X, lequel anion est un anion pharmaceutiquement acceptable d'un acide mono ou polyvalent.

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