Combinations comprising antimuscarinic agents and pde4...

A - Human Necessities – 61 – K

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A61K 31/439 (2006.01) A61K 31/277 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01)

Patent

CA 2569074

A combination which comprises (a) a PDE4 inhibitor and (b) an antagonist of M3 muscarinic receptors which is (3R)-1-phenethyl-3-(9H-xanthene-9~carbonyloxy)-1- azoniabicyclo[2.2.2]octane, in the form of a salt having an anion X, which is a pharmaceutically acceptable anion of a mono or polyvalent acid.

Cette invention concerne une combinaison comprenant (a) un inhibiteur de PDE4 et (b) un antagoniste des récepteurs muscariniques de type M3, soit (3R)-1-phenéthyl-3-(9H-xanthène-9-carbonyloxy)-1-azoniabicyclo[2.2.2]octane, sous la forme d'un sel ayant un anion X, qui est un anion pharmaceutiquement acceptable d'un acide mono- ou polyvalent.

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