Combinations comprising dmxaa for the treatment of cancer

A - Human Necessities – 61 – K

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Details

A61K 31/352 (2006.01) A61K 31/337 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2620436

The present invention relates to combinations of compounds such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and vascular endothelial growth factor binders, in particular the monoclonal antibody AvastinTM (bevacizumab). More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical formulations containing such combinations.

La présente invention concerne des combinaisons de composés tels que des composés de la classe de l'acide xanthénone acétique, comme l'acide 5,6-diméthylxanthénone-4-acétique (DMXAA), et de liants de facteur de croissance de l'endothélium vasculaire, en particulier l'anticorps monoclonal Avastin~ (bevacizumab). Cette invention concerne plus particulièrement l'utilisation de telles combinaisons pour traiter le cancer, ainsi que des préparations pharmaceutiques comprenant ces combinaisons.

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