A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/425 (2006.01) A61K 31/565 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2478223
The invention relates to a pharmaceutical combination which comprises (a) an alkylating agent and (b) an epothilone derivative of formula (I) wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond. Said combination can be useful for the treatment of a proliferative disease, especially a tumor disease.
L'invention concerne un mélange pharmaceutique comprenant (a) un alcoylant et (b) un dérivé d'épothilone représenté par la formule (I), dans laquelle A représente O ou NR<SB>N</SB>, R<SB>N</SB> représentant hydrogène ou alkyle inférieur, R représente hydrogène ou alkyle inférieur, et Z représente O ou une liaison. Ce mélange peut être utile dans le traitement d'une maladie proliférative, plus spécifiquement d'une maladie tumorale.
Anderson Judith Rose
Boddy Alan
Mc Sheehy Paul M.j.
Rothermel John David
Fetherstonhaugh & Co.
Novartis Ag
University Of Newcastle Upon Tyne
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