Combinations comprising staurosporines

A - Human Necessities – 61 – K

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Details

A61K 31/553 (2006.01) A61K 31/343 (2006.01) A61K 31/475 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2533861

The present invention relates to a method of treating myelodysplastic syndromes, lymphomas and leukemias, and also solid tumors with a pharmaceutical combination of a FLT-3 kinase inhibitor and a histone deacetylase inhibitor (HDAI). It also relates to the use of a pharmaceutical combination of a histone deacetylase inhibitor and a FLT-3 kinase inhibitor for the treatment of the diseases or malignancies mentioned above and the use of such a pharmaceutical composition for the manufacture of a medicament for the treatment of these diseases or malignancies.

L'invention concerne une méthode de traitement des syndromes myélodysplasiques, des lymphomes, des leucémies ainsi que des tumeurs solides, au moyen d'une combinaison pharmaceutique contenant un inhibiteur de la kinase FLT-3 et un inhibiteur de l'histone déacétylase (HDAI). Par ailleurs, l'invention concerne l'utilisation d'une combinaison pharmaceutique contenant un inhibiteur de l'histone déacétylase et un inhibiteur de la kinase FLT-3 dans le traitement des maladies ou des tumeurs malignes précitées, ainsi que l'utilisation de cette combinaison pharmaceutique dans la fabrication d'un médicament destiné à traiter lesdites maladies ou tumeurs malignes.

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