A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/553 (2006.01) A61K 45/06 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2655724
The present invention relates to a method of treating myelodysplastic syndromes, lymphomas and leukemias, and also solid tumors with a pharmaceutical combination of a FLT-3 kinase inhibitor and an antisense oligonucleotide or a mcl-1 -specific RNAi construct. It also relates to the use of a pharmaceutical combination of a histone deacetylase inhibitor and a FLT-3 kinase inhibitor for the treatment of the diseases or malignancies mentioned above and the use of such a pharmaceutical composition for the manufacture of a medicament for the treatment of these diseases or malignancies.
La présente invention concerne un procédé de traitement des syndromes myélodysplasiques, des lymphomes, des leucémies et des tumeurs solides au moyen d'une combinaison pharmaceutique contenant un inhibiteur de la kinase FLT-3 et un oligonucléotide antisens ou une construction d'ARN interférent (iRNA) spécifique à Mcl-1. L'invention concerne également l'utilisation d'une combinaison pharmaceutique contenant un inhibiteur de l'histone désacétylase et un inhibiteur de la kinase FLT-3 dans le cadre du traitement des maladies ou tumeurs précitées, ainsi que l'utilisation d'une telle composition pour fabriquer un médicament destiné à traiter lesdites maladies ou tumeurs malignes.
Fetherstonhaugh & Co.
Novartis Ag
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