A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/52 (2006.01) A61K 31/7072 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2258956
The present invention relates to therapeutic combinations of 3S-[3R*(1R*,2S*)- [3-[[(4-aminophenyl)sulphonyl](2-methylpropyl)-amino]-2-hydroxy-1-phenyl- methyl)propyl]carbamic acid, tetrahydro-3-furanyl ester (141W94), 3'-azido-3'- déoxythymidine (zidovudine) and (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3- oxathiolan-5-yl)-(1H)-pyrimidin-2-one (3TC) (or, alternatively to 3TC, (2R,cis)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)- pyrimidin-2-one (FTC)) which have anti-HIV activity. The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HIV infections including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors.
L'invention concerne des combinaisons thérapeutiques d'acide 3S-[3R*(1R*,2S*)]-[3-[[(4-aminophényl)sulphonyl](2-méthylpropyl)-amino]-2-hydroxy-1-phényl-méthyl)propyle]carbamique, d'ester tétrahydro-3-furanyl (141W94), de 3'-azido-3'-désoxythymidine (zidovudine) et (2R,cis)-4-amino-1-(2-hydroxyméthyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (3TC) (ou éventuellement, du 3TC, (2R,cis)-4-amino-5-fluoro-1-(2-hydroxyméthyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (FTC) qui présentent une activité anti-VIH. La présente invention concerne aussi des compositions pharmaceutiques contenant ces combinaisons et leur utilisation pour traiter les infections par le VIH, dont les infections par des mutants du VIH offrant une résistance aux inhibiteurs nucléosides et/ou non nucléosides.
Barry David Walter
St. Clair Martha Heider
Glaxo Group Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
Combinations comprising vx478, zidovudine, ftc and/or 3tc... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combinations comprising vx478, zidovudine, ftc and/or 3tc..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinations comprising vx478, zidovudine, ftc and/or 3tc... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1978920