Combinations for introducing nucleic acids into cells

Details Combinations for introducing nucleic acids into cells Combinations for introducing nucleic acids into cells

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 48/00 (2006.01) C08L 71/02 (2006.01) C08L 89/00 (2006.01)

Patent

CA 2377207

The invention relates to combinations of a carrier and a complex, which consists of a nucleic-acid molecule and a copolymer. Said copolymer consists of an amphiphilic polymer, preferably polyethylene glycol and a charged effector molecule, in particular, a peptide or peptide derivative. The invention also relates to the use of the combinations for transferring nucleic acid molecules into cells.

L'invention concerne des combinaisons comprenant un support et un complexe constitué d'une molécule d'acide nucléique et d'un copolymère, ce copolymère étant lui-même constitué d'un polymère amphiphile, de préférence de polyéthylèneglycol, et d'une molécule effectrice chargée, en particulier un peptide ou un dérivé de peptide. L'invention concerne également l'utilisation de ces combinaisons pour le transfert de molécules d'acides nucléiques dans des cellules.

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