Combinations for the treatment of b-cell proliferative...

Details Combinations for the treatment of b-cell proliferative... Combinations for the treatment of b-cell proliferative...

A - Human Necessities

61

K

A61K 31/7076 (2006.01) A61K 31/18 (2006.01) A61K 31/4015 (2006.01) A61K 31/44 (2006.01) A61K 31/444 (2006.01) A61K 31/4709 (2006.01) A61K 31/472 (2006.01) A61K 31/50 (2006.01) A61K 31/519 (2006.01) A61P 11/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2694987

The invention features compositions and methods employing combinations of an A2A receptor agonist and a PDE inhibitor for the treatment of a B-cell proliferative disorder, e g, multiple myeloma In at least one embodiment, the compositions of the invention comprise a PDE inhibitor active against at least two of PDE 2, 3,4, and 7 In at least one embodiment, the compositions of the invention compnse further administenng an antiproliferative compound.

L'invention concerne des compositions et des procédés employant des combinaisons d'un agoniste du récepteur A2A et d'un inhibiteur PDE dans le traitement d'un trouble prolifératif de lymphocytes B, comme par exemple un myélome multiple. Dans au moins une forme de réalisation de l'invention, les compositions de l'invention comprennent un inhibiteur PDE actif contre au moins deux des PDE 2, 3, 4 et 7. Dans au moins une forme de réalisation, les compositions de l'invention compensent l'administration en plus d'un composé antiprolifératif.

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