Combinations, methods and compositions for treating cancer

Details Combinations, methods and compositions for treating cancer Combinations, methods and compositions for treating cancer

A - Human Necessities

61

K

A61K 31/5513 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2604581

The invention relates to a combination of BCR-ABL inhibitor, exemplified by 'N- (2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4- pyrimidinyl]amino]-5-thiazolecarboxamide and/or other BCR/ABL inhibitors, and a stem cell selective cytotoxic, exemplified by (R)-2,3,4,5-tetrahydro-1-(1H- imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4- benzodiazepine-7-carbonitrile, hydrochloride salt, and or other stem cell cytotoxic agents, pharmaceutical compositions of the combination and to methods of using the pharmaceutical compositions in the treatment of oncological disorders.

L'invention concerne une combinaison d'un inhibiteur de BCR-ABL, tel que 'N-(2-Chloro-6-méthylphényl)-2-[[6-[4-(2-hydroxyéthyl)-1-pipérazinyl]-2-méthyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide et/ou d'autres inhibiteurs de BCR/ABL, et d'un agent cytotoxique sélectif de cellules souches, tel que (R)-2,3,4,5-tétrahydro-1-(1H-imidazol-4-ylméthyl)-3-(phénylméthyl)-4-(2-thiénylsulfonyl)-1H-1,4-benzodiazépine-7-carbonitrile, d'un sel d'hydrochlorure, et/ou d'autres agents cytotoxiques de cellules souches. Par ailleurs, l'invention concerne des compositions pharmaceutiques de cette combinaison ainsi que des procédés d'utilisation de ces compositions pharmaceutiques dans le traitement de troubles oncologiques.

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